RABS often used integrated with filling and freeze drying processing line for large scale production

RABS is used to reduce the contamination risk by physical barrier. Doors are not allowed open during production unless the intervention is fully validated not introduce contamination or disrupt the unidirectional airflow. Sensors are amount on each door to detect and record the opening and warning or alarming will trigged if the doors are opened.

A filter Unidirectional airflow (Grade A) is designed inside RABS to protect the critical area.  Pressure differential gages are equipped to monitor the pressure across the HEPA filters. Anemometers are used to detect the air velocity. Online particle counters and microbe sampler are equipped.

The air used for the unidirectional air flow is exhausted into the production room (Grade B). For this reason the RABS is not suitable used to deal with toxic products.